Are you getting an error similar to what you can see below?
Let's do the following:
1) Download the following OpenCL.dll and put it in your installation directory: C:\Program Files\Topaz Labs LLC\Topaz Sharpen AI:
2) Make sure your GPU (graphics card) driver is up to date: Updating your GPU.
-In case you still need any help, please submit a ticket through our Help Center.