You can't access Sharpen AI as a plugin or it's grayed out in Photoshop? You can manually configure the plugin:
1) Make sure you have Photoshop closed and go to Applications >> Topaz Labs LLC >> Topaz Sharpen AI >> Right-click Topaz Sharpen AI app icon and select ''Show Package Content'' >> Contents >> Resources >> PS_Plugins >> Copy the plugin file ''TopazSharpenAI.plugin''.
2) Paste the plugin file ''TopazSharpenAI.plugin'' in the path: /Library/Application Support/Adobe/Plug-Ins/CC
Note: You can go to that path by opening a new Finder window and open the Go to Panel by holding down CMD (Command) + Shift + G
-If you still need any further help, please submit a ticket through our Help Center.